Biological Treatment Technology Center
Biological Treatment Technology Center

The Biological Treatment Technology Center, formerly known as the Lingnan Cord Blood Bank and Stem Cell Research Center of the Second Affiliated Hospital of the former Sun Yat-sen University of Medical Sciences, has been conducting umbilical cord hematopoietic stem cell and peripheral blood stem cell transplantation therapies since 1997. In 2010, it was officially renamed the Center for Biotherapy Technology and pioneered immunocellular therapies (including TCR-T, CAR-T, TIL, DC-CIK, etc.), mesenchymal stem cell therapy, and highly activated T lymphocyte immunotherapy in China. The center holds dual certifications as one of the earliest nationally approved Stem Cell Clinical Research Institutions (2017) and one of the first National Somatic Cell Clinical Research Institutions (2024) in the country.
  The center currently has 19 staff members, including 3 senior professionals, 4 intermediate professionals, and 8 junior professionals. It employs 2 doctoral supervisors and 1 master's supervisor, with Professor Su Shicheng serving as the academic leader. The team comprises individuals with research backgrounds in clinical medicine, basic medicine, laboratory medicine, life sciences, and pharmacy, demonstrating strong capabilities in scientific innovation and clinical translation.
  The center consists of the Cell Preparation Center at the Northern Campus and the Biobank at the Southern Campus. The Northern Campus Cell Preparation Center focuses on the research and translation of immune cell and stem cell therapy technologies. It is equipped with a GMP cell laboratory, a cell quality testing room, and a basic research platform, featuring facilities such as flow cytometers, single-cell gene expression quantitative profiling systems, live-cell workstations, quantitative PCR amplification systems, fully automated blood culture systems, microplate readers, and ultracentrifuges. The center has established a scalable production and quality management system for stem cells and immune cells, enabling independent capabilities in cell-based formulation development, preparation, and testing.
  The Southern Campus Biobank serves as a demonstration biobank for Sun Yat-sen University and the Biobank Management Center for the National Major Science and Technology Project on Drug Clinical Research and Evaluation Platforms, with a total storage capacity of 2 million samples. The biobank has implemented a Linux-based sample resource management system that integrates with electronic medical records, pathology, surgery, imaging, and laboratory systems, achieving an automated, standardized, and intelligent sample resource repository. This management system stores over 300 disease types, covering major diseases, region-specific conditions, and rare diseases, forming specialized disease resource repositories with a focus on disciplines such as breast tumors and urological tumors.
  The Center for Biotherapy Technology adheres to the philosophy of "putting people first and striving for excellence," guided by the principle of "respecting life and providing sincere care." It is committed to delivering high-quality medical services to patients. The center focuses on clinical challenges to drive innovative research into disease mechanisms and therapeutic targets, while also developing biotherapeutic products such as immune cells, stem cells, biological vaccines, and antibodies for clinical applications.

Featured Medical Technology

The Biological Treatment Technology Center was a national pioneer in introducing immunocellular therapies (such as TCR-T, CAR-T, TIL, DC-CIK, etc.), mesenchymal stem cell therapy, and highly activated T lymphocyte immunotherapy. It is also designated as a pilot medical institution under the Guangzhou Social Medical Insurance Fund for the "Management of Medical Treatment and Expense Settlement for Autologous Immune Cell Therapy for Insured Individuals."
As a platform for cell preparation, biopharmaceutical research and development, and biobank storage, the center maintains long-term and close collaboration with multiple clinical research teams within our hospital. These include the Breast Tumor Center, Department of General Practice, Department of Orthopedics, Department of Pediatrics, Department of Neurology, Department of Dermatology, Department of Hematology, Department of Rehabilitation Medicine, and Department of Oncology. Together, they conduct research on cell therapies and manage biobank storage for diseases such as malignant tumors, ankylosing spondylitis, osteoarthritis, chronic graft-versus-host disease, myasthenia gravis, cerebral infarction, and recurrent miscarriage.

Scientific Research Results

The department has undertaken multiple research projects funded by the Ministry of Science and Technology, the National Natural Science Foundation of China, the National Health Commission, as well as Guangdong Province and Guangzhou City. Guided by a clinical problem-oriented philosophy, the team has conducted a series of studies addressing clinical challenges, yielding substantial outcomes. Over the past five years, research findings have been published in top-tier international academic journals, including Nature, Cell, Nature Immunology, Nature Cell Biology, Nature Communications, Advanced Science, Clinical Cancer Research, Cancer Research, International Journal of Cancer, and Advanced Composites and Hybrid Materials.