Center for Cellular and Molecular Diagnostics
Center for Cellular and Molecular Diagnostics

This center was established in 2016 and is primarily responsible for two main functions: clinical cytopathology diagnosis and molecular diagnosis across the entire hospital. It currently occupies an area of over 900 square meters, which includes a standard 150-square-meter next-generation sequencing (NGS) laboratory. The center has established various cellular and molecular technology platforms, including liquid-based cytology preparation, cell block sectioning, immunohistochemistry, flow cytometry, multiplex flow immunofluorescence (Luminex), fluorescence in situ hybridization (FISH), quantitative PCR, gene microarray, Sanger sequencing, and next-generation sequencing. It is equipped with a large-scale clinical bioinformatics analysis system capable of independently performing sequencing and interpretation for whole-exome sequencing, tumor panels (large, medium, and small), metagenomics, and other applications. The center currently employs over 60 staff, including 22 cytopathologists and clinical bioinformatics specialists, 11 of whom hold doctoral degrees.
  Cytopathology services encompass cervical cytology screening, non-gynecologic exfoliative cytology, and fine-needle aspiration cytology. The center routinely employs a diagnostic model combining liquid-based cytology with cell block sectioning, supplemented by immunohistochemistry and molecular testing when necessary. This approach has significantly enhanced the diagnostic accuracy for challenging cases such as thyroid cancer, lung cancer, lymph node lesions, pleural and peritoneal effusions, and head and neck tumors. In molecular diagnosis, the center offers genetic testing across nearly all fields, including oncology, genetic/metabolic disorders, prenatal diagnosis, transplantation matching, hematologic diseases, and microbiology. It possesses strong capabilities in the clinical interpretation of large-scale NGS projects, such as comprehensive tumor panels, whole-exome sequencing, metagenomics, non-invasive prenatal testing (NIPT), and gene microarrays.
  This center is recognized as a demonstration laboratory by the National Pathology Quality Control Center (PQCC). It has established a robust internal quality control system and actively participates in external quality assessments for genetic testing and cytopathology conducted by authoritative bodies such as the National Pathology Quality Control Center under the National Health Commission, the National Center for Clinical Laboratories, and the Guangdong Provincial Pathology Quality Control Center, consistently achieving excellent results in annual evaluations. In recent years, the center has also participated in multiple clinical trials and assisted in obtaining Class III Medical Device Certifications.
  The center serves as a key national training base for clinical bioinformatics specialists, NGS technicians, and cytopathologists. It has successfully organized multiple sessions of training programs in clinical bioinformatics, thyroid cytopathology diagnosis, NGS, and various molecular techniques. Participants and observers from over 30 provinces and municipalities across the country, totaling more than 10,000 individuals, have attended these programs, fully demonstrating the center's exemplary role and diagnostic authority in cellular and molecular testing.

Featured Medical Technology

1.Cytopathology Diagnosis — Minimally Invasive/Non-Invasive Pathological Diagnosis
2.Molecular Diagnosis (Genetic Testing) — Comprehensive Coverage for Precision Diagnosis in Oncology, Genetics, Infectious Diseases, and More

Scientific Research Results

It has trained over 10,000 molecular technicians, cytopathologists, and clinical bioinformatics specialists. The center has led the development of a series of industry standards and guidelines, including the group standard "Classification of High-Throughput Gene Sequencing Projects," the "Guangdong Expert Consensus on Gene Testing and Clinical Application for Thyroid Cancer (2020 Edition)," the "Expert Consensus on RET Gene Testing and Clinical Application for Thyroid Cancer (2021 Edition)," the "Chinese Expert Consensus on Reporting Template 1.0 for High-Throughput Sequencing-Based Gene Testing of Thyroid Tumors (2023 Edition)," and the "Chinese Guidelines for Integrated Diagnosis and Treatment of Tumors (CACA) – Gene Testing (2023 Edition)." Additionally, the center has spearheaded the establishment of the Cytopathology and Molecular Diagnosis Committee of the Guangdong Primary Medicine Association and the Clinical Bioinformatics Branch of the Guangdong Precision Medicine Application Association. In scientific research, it has undertaken five National Natural Science Foundation projects, three Postdoctoral Foundation projects, and three Provincial Natural Science Foundation projects over the past five years, and has published over 70 SCI-indexed papers.