Doctor Yao is a clinician scientist who is keen to address scientific questions derived from clinical practice. He has demonstrated that breast preservation maintains the microenvironment tissues for activation of anti-tumor immunity by subsequent conventional anti-tumor treatments. He also studies the regulatory roles of tumor microenvironment in cancer progression, and has achieved a series of original findings. For example, he has uncovered variousCombination of two or more therapeutic strategies with different mechanisms can cooperatively prohibit cancer development. Combination of chemotherapy and small interfering RNA (siRNA)-based therapy represents an example of this approach.