中山大学孙逸仙纪念医院医学研究中心课题组负责人。武汉大学生命科学学院学士,上海交大医学院/上海生命科学研究院 健康所硕士,德国埃尔朗根-纽伦堡大学博士,德国汉堡艾本多夫医学中心和英国爱丁堡大学皇后医学研究所博士后。
联系方式:huangjg35@mail.sysu.edu.cn
研究方向:主要从事成纤维细胞和免疫细胞互作介导组织器官纤维化、炎症和癌症等疾病的新机制和干预新靶点研究。
学术成绩:
发表1篇Nature Communications(2018共一、共通讯 IF 17.694),3篇Annals of the Rheumatic Diseases(2016第一;2017共一第一;2022共通讯 IF 27.973),1篇Life Medicine(2022共通讯),FASEB J(2023共通讯 IF 5.834),Cell Oncol (Dordr)(2024共通讯 IF6.6),Front Immunol (2024最后通讯 IF 5.7),Fundamental Research(2024共通讯 IF 5.7)。此外,以合作者身份在Nature Medicine(IF 87.241),Sci Transl Med(IF 19.319), Advanced science(IF 17.521),Arthritis Res Ther等国际知名学术期刊发表相关论文近25篇,论文引用近1377次,申请发明专利1项等,曾获得 “国家优秀自费留学生奖”,并在罗马、旧金山、上海、广州和福州等国内外大会做口头报告交流7次。
主持中山大学“百人计划”引进人才、中央高校青年教师培育项目(重点项目)、上海市骨科内植物实验室开放课题、广东省面上和参与区域联合基金-重点项目等基金项目
代表论著 (#第一作者,*通讯作者)
- Chen, J.#, R. Chen# and J. Huang* (2024). "A pan-cancer single-cell transcriptional analysis of antigen-presenting cancer-associated fibroblasts in the tumor microenvironment." Front Immunol 15: 1372432.(中科院二区 IF 5.7)
- Xu, X.#, C. Lai#, J. Luo#, J. Shi, K. Guo, J. Hu, Y. Mulati, Y. Xiao, D. Kong, C. Liu, J. Huang* and K. Xu* (2024). "The predictive significance of chromobox family members in prostate cancer in humans." Cell Oncol (Dordr).(中科院二区 IF 6.6)
- Guo, C., L. Liang, J. Zheng, Y. Xie, X. Qiu, G. Tan, J. Huang* and L. Wang* (2023). "UCHL1 aggravates skin fibrosis through an IGF-1-induced Akt/mTOR/HIF-1alpha pathway in keloid." FASEB J 37(7): e23015.(中科院二区 IF 5.834)
- Qin, Y.#, M. L. Cai#, H. Z. Jin, W. Huang, C. Zhu, A. Bozec, J. Huang* and Z. Chen* (2022). "Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-alpha-mediated ERK1/2 and JAK-STAT1 pathways." Ann Rheum Dis 81(11): 1504-1514. (中科院一区 IF: 28.003)
- Zehender, A.#, J. Huang#*, A. H. Gyorfi, A. E. Matei, T. Trinh-Minh, X. Xu, Y. N. Li, C. W. Chen, J. Lin, C. Dees, C. Beyer, K. Gelse, Z. Y. Zhang, C. Bergmann, A. Ramming, W. Birchmeier, O. Distler, G. Schett and J. H. W. Distler*(2018). "The tyrosine phosphatase SHP2 controls TGFbeta-induced STAT3 signaling to regulate fibroblast activation and fibrosis." Nat Commun 9(1): 3259. (中科院一区 IF:14.919)
- Huang, J. #, C. Maier#, Y. Zhang, A. Soare, C. Dees, C. Beyer, U. Harre, C. W. Chen, O. Distler, G. Schett, L. Wollin and J. H. W. Distler* (2017). "Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis." Annals of the Rheumatic Diseases 76(11): 1941-1948. (中科院一区 IF:19.103)
- Huang, J. G., C. Beyer, K. Palumbo-Zerr, Y. Zhang, A. Ramming, A. Distler, K. Gelse, O. Distler, G. Schett, L. Wollin and J. H. W. Distler* (2016). "Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis." Annals of the Rheumatic Diseases 75(5): 883-890. (中科院一区 IF:19.103)