学科专业：基础医学（分子医学）

研究方向：肿瘤微环境与肿瘤耐药

电子邮箱：sulp@mail.sysu.edu.cn

个人简介

苏良平，中山大学孙逸仙纪念医院医学研究中心副研究员、硕士研究生导师。主要研究方向：围绕肿瘤代谢重编程和表观遗传修饰，探讨肿瘤微环境调控肿瘤耐药、抑制细胞焦亡的分子机制。利用组织芯片、类器官模型及小鼠模型，鉴定调控肿瘤微环境抑制细胞焦亡影响肿瘤耐药的关键分子，为防治肿瘤耐药开辟新的思路。近五年，以（共同）第一作者在Science Translational Medicine、Cell Report、Redox Biology、Cancer Letters、Pharmacological Research、npj Precision Oncology等国际主流学术期刊发表SCI论文7篇，申请发明专利2项。目前主持国家自然科学基金、中国博士后站中特别资助、中国博士后面上项目等科研项目。

论文成果代表：

[1] Liangping Su, et al.,Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models. Science Translational Medicine (1946-6234). 2023, 15(678): eabl7895.1-18.（第一作者，IF=19.319）

[2] Liangping Su, et al.. Muscle-specific histone H3K36 dimethyltransferase SET-18 shortens lifespan of Caenorhabditis elegans by repressing daf-16a expression. Cell Rep, 2018, 22(10): 2716-29.第一作者，IF=9.995）

[3] Liangping Su, et al..Chemoresistant fibroblasts dictate neoadjuvant chemotherapeutic response of head and neck cancer via TGFα-EGFR paracrine signaling.  npj Precision Oncology, 2023. （第一作者，IF=7.9）

[4] Lei-Bo Xu; Yu-Fei Qin; Liangping Su; Cheng Huang; Qiuping Xu; Rui Zhang; Xiang-De Shi; Ruipu Sun; Jiali Chen; Zhixiao Song; Xue Jiang; Lihuan Shang; Gang Xiao; Xiangzhan Kong; Chao Liu*; Ping-Pui Wong*; Cathepsin-facilitated invasion of BMI1-high hepatocellular carcinoma cells drives bile duct tumor thrombi formation, Nature Communications, 2023, 14(1)（共一第三作者，IF=16.6）

[5] Hongyuan Li, Liangping Su, et al., Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans. Redox biology, 2019, 21(101111.（共一第二作者，IF=10.787）

[6] Yitian Chen, Liangping Su, et al., Galactosyltransferase B4GALT1 confers chemoresistance in pancreaticductal adenocarcinomas by upregulating N-linked glycosylationof CDK11p110，Cancer Lett. 2021;500:228-43. （共一第二作者，IF=9.756）

[7] Cheng Huang, Liangping Su, et al. Ceramide kinase confers tamoxifen resistance in estrogen receptor-positivebreast cancer by altering sphingolipid metabolism. Pharmacological Research,Volume 187, January 2023, 106558.（共一第二作者，IF=10.334）

[8] Liangping Su, et al..ELT-2 promotes O‐GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan. J Cell Biochem, 2020. （第一作者，IF=4.429）