副研究员，博士生导师，PI，广东省“特支计划”科技创新青年拔尖人才。

研究领域：从2009年开始至今一直从事蛋白翻译后修饰与肿瘤基因组不稳定性、细胞周期调控紊乱及肿瘤放化疗、靶向治疗耐受等方面的分子机制研究，在肿瘤发生发展及耐药机制等方向取得一系列重要的原创性成果，共发表20多篇相关的第一或通讯(含共同)SCI学术论文，其中包括6篇影响因子>10，包括Journal of Clinical Investigation、Advanced Science、Molecular Psychiatry、EMBO Report、Oncogene（3篇）、Signal Transduction and Targeted Therapy、Journal of biological chemistry（2篇）等；作为项目负责人获得5项国家自然科学基金项目资助(青年基金1项，面上项目4项)，获批2项国家发明专利；Oncogene、Oncogenesis、Cell Death & Disease、BBA等期刊同行评议专家。

联系方式：huksh3@mail.sysu.edu.cn

主持的部分基金项目：

(1) 国家自然科学基金面上项目，82573408，2026/01-2029/12，49万元，在研，主持；

(2) 国家自然科学基金面上项目，82373150，2024/01-2027/12，48万元，在研，主持；

(3) 国家自然科学基金面上项目，82172636，2022/01-2025/12，55万元，在研，主持；

(4) 国家自然科学基金面上项目，81772821，2018/01-2021/12，52万元，已结题，主持；

(5) 国家自然科学基金青年项目，81301732，2014/01-2016/12，23万元，已结题，主持；

(6) 广东省特支计划“科技创新青年拔尖人才”项目，2021TQ06Y125，2022/11-2025/10，50万元，在研，主持；

近五年代表性论文(#第一作者，*通讯作者)：

1、Wenjing Wu^#, Weijun Wu^#, Xiaojuan Xie^#, Jing Li^#, Yuan Gao, Limin Xie, Caixia Zhong, Jianhong Xiao, Manbo Cai*, Dong Yin*, Kaishun Hu* (通讯作者). DNMT1 is required for efficient DSB repair and maintenance of replication fork stability, and its loss reverses resistance to PARP inhibitors in cancer cells. Oncogene. 2025 Jul;44(27):2283-2302.

2、Yingshi Zhou^#, Zhihuai Deng^#, Shiyu Xiong^#, Wenjia Li^#, Wanrong Luo, Man Luo, Haifeng Tang, Wenjing Wu, Carmen Chak-Lui Wong, Dong Yin*, Kaishun Hu* (共同通讯作者), Baoming Luo*. NUDT16 enhances the resistance of cancer cells to DNA-damaging agents by regulating replication fork stability via reversing HMGA1 ADP-ribosylation. J Biol Chem. 2025 Apr 25;301(6):108551.

3、Jiefu Zheng^#, Yawen Deng^#, Cong Fang^#, Shiyu Xiong, Xudong Zhu, Weijun Wu, Xinliang Chen, Wenjing Wu, Dong Yin*, Kaishun Hu*(共同通讯作者), Haiyan Yan*. Comprehensive dataset of interactors for the entire PARP family using TurboID proximity labeling. Sci Data. 2025 Mar 8;12(1):405.

4、Kaishun Hu^#(第一作者), Yu Li^#, Wenjing Wu^#, Limin Xie^#, Haiyan Yan, Yuexin Cai, Dong Chen, Qiongchao Jiang, Lehang Lin, Zhen Chen, Jian-You Liao, Yin Zhang, H Phillip Koeffler, Dong Yin*, Erwei Song*，ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions，Adv Sci (Weinh). 2020 Sep 3;7(20):2000157.

5、Kaishun Hu^#(第一作者), Wenjing Wu^#, Yu Li^#, Lehang Lin, Dong Chen, Haiyan Yan, Xing Xiao, Hengxing Chen, Zhen Chen, Yin Zhang, Shuangbing Xu, Yabin Guo, H Phillip Koeffler, Erwei Song*, Dong Yin*，Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents，EMBO Rep. 2019 May;20(5): e46166.

6、Weijun Wu^#, Wenjing Wu^#, Yingshi Zhou^#, Qiao Yang^# , Shuting Zhuang, Caixia Zhong, Wenjia Li, Aixin Li, Wanzhen Zhao, Xiaomin Yin, Xuyu Zu, Carmen Chak-Lui Wong, Dong Yin*, Kaishun Hu*(共同通讯作者), Manbo Cai*, The dePARylase NUDT16 promotes radiation resistance of cancer cells by blocking SETD3 for degradation via reversing its ADP-ribosylation. J Biol Chem. 2024 Jan 23:105671.

7、Wenting Guo^#, Weijun Wu^#, Yan Wen, Yuan Gao, Shuting Zhuang, Chunyan Meng, Haitao Chen, Zhipeng Zhao, Kaishun Hu*(共同通讯作者), Baixing Wu*, Structural insights into the catalytic mechanism of the AP endonuclease AtARP.

Structure, 2024 Jun 6;32(6):780-794.e5.

8、Wenjia Li^#, Qingfang Han^#, Yuanxin Zhu^#, Yingshi Zhou^#, Jingyuan Zhang, Weijun Wu, Yu Li, Long Liu, Yuntan Qiu, Kaishun Hu*(共同通讯作者), Dong Yin*, SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma. Oncogene. 2023 Apr 7.

9、Fangfang Qi^#, Zejie Zuo^#, Kaishun Hu^#(共同第一作者), Rui Wang, Tong Wu, Hao Liu, Jiaoling Tang, Qingbo Wang, Yufeng Xie, Liren Tan, Yunjie Yang, Xiaoran Zhang, Jiaying Zheng, Jie Xu, Zhibin Yao, Shengwen Wang*, Long-Jun Wu*, Kaihua Guo*，VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration. Mol Psychiatry. 2023 Jun 6.

10、Yang Yang^#, Yuedong Ma^#, Huabin Gao^#, Tingsheng Peng, Huijuan Shi Yunxiang Tang, Hui Li, Lin Chen, Kaishun Hu*(共同通讯作者), Anjia Han*，A novel HDGF-ALCAM axis promotes the metastasis of Ewing sarcoma via regulating the GTPases signaling pathway. Oncogene. 2021 Jan;40(4):731-745.

11、Liwen Zhou^#, Lisi Zheng^#, Kaishun Hu^#(共同第一作者), Xin Wang, Ruhua Zhang, Yezi Zou, Li Zhong, Shang Wang, Yuanzhong Wu*, Tiebang Kang*，SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites. Signal Transduct Target Ther. 2020 Jun 24;5(1):80.

12、Wenjing Wu^#, Jianli Zhao^#, Jianhong Xiao, Weijun Wu, Limin Xie, Xiaojuan Xie, Chaoye Yang, Dong Yin*, Kaishun Hu*(通讯作者). CHFR-mediated degradation of RNF126 confers sensitivity to PARP inhibitors in triple-negative breast cancer cells, Biochem Biophys Res Commun. 2021 Oct 8;573: 62-68.

13、Yu Li^#, Xing Xiao^#, Hengxing Chen, Zhen Chen, Kaishun Hu*(共同通讯作者), Dong Yin*. Transcription factor NFYA promotes G1/S cell cycle transition and cell proliferation by transactivating cyclin D1 and CDK4 in clear cell renal cell carcinoma, Am J Cancer Res. 2020 Aug 1;10(8):2446-2463.

14、Hengxing Chen^#, Yun Li^#, Yu Li, Zhen Chen, Limin Xie, Wenjia Li, Yuanxin Zhu, Hong Xue, H Phillip Koeffler, Wenjing Wu, Kaishun Hu*(共同通讯作者), Dong Yin*. PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2. Theranostics. 2020 Aug 8;10(22):9984-10000.