职称：研究员

导师资格：博士生导师

研究方向：肿瘤基因组学和肿瘤分子遗传学；肿瘤基因表观调控；肿瘤DNA损伤修复与耐药机制

联系方式：yind3@mail.sysu.edu.cn

简介：

遗传物质变异的积累是肿瘤发生发展的重要原因之一。多年来，围绕肿瘤的遗传和表观遗传学展开深入研究。包括肿瘤的基因突变和表达、核酸和组蛋白修饰、染色质重塑、DNA损伤修复等。发现多个肿瘤相关基因的遗传和表观遗传改变，揭示细胞周期调控异常与肿瘤发生发展，以及DNA损伤修复与肿瘤耐药的机制。发表论文近百篇，总引用6900多次，H指数45（来自Google Scholar），其中以第一/通讯作者（含共同）在Advance Science、Cancer Research、Nucleic Acids Research、Clinical Cancer Research、Oncogene等杂志发表SCI研究论文60余篇。

代表论著

1.Yuanxin Zhu, Wenjia Li, Yuntan Qiu, Zhihuai Deng, Yu Li, Hengxing Chen, Jingyuan Zhang, Daning Lu, Kaishun Hu, Dongsheng Huang, Dong Yin*. HP1 enhances radio- and chemotherapy resistance in osteosarcoma via PARP1-dependent transcriptional repression and HR repair. Cancer letters. 2025 Dec. DOI:10.1016.

2.Yang B, Zhang M, Shi Y, Zheng BQ, Shi C, Lu D, Yang ZZ, Dong YM, Zhu L, Ma X, Zhang J, He J, Zhang Y, Hu K, Lin H, Liao JY, Yin Dong*. PerturbDB for unraveling gene functions and regulatory networks. Nucleic Acids Research. 2025 Jan 6;53(D1):D1120-D1131. doi: 10.1093/nar/gkae777.

3. Li W, Han Q, Zhu Y, Zhou Y, Zhang J, Wu W, Li Y, Liu L, Qiu Y, Hu K*, Yin Dong*. SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma. Oncogene. 2023 May;42(21):1728-1740.

4. Li Y, Chen H, Xie X, Yang B, Wang X, Zhang J, Qiao T, Guan J, Qiu Y, Huang YX, Tian D, Yao X, Lu D, Koeffler HP, Zhang Y*, Yin Dong*. PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells. Cancer Research. 2023 Feb 3;83(3):398-413.

5. Yongsheng Huang#, Qian Yang#, Yueyuan Zheng#, Lehang Lin#, Xin Xu, Xiu-E Xu, Tiago C Silva, Masaharu Hazawa, Li Peng, Haotian Cao, Yanbing Ding, Daning Lu, Benjamin P Berman, Li-Yan Xu*, En-Min Li*, Yin Dong*. Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma. Nucleic Acids Research. 2021 Aug 9;gkab679.

6. Zhang Y, Huang YX, Jin X, Chen J, Peng L, Wang DL, Li Y, Yao XY, Liao JY, He JH, Hu K, Lu D, Guo Y*, Yin Dong*. Overexpression of lncRNAs with endogenous lengths and functions using a lncRNA delivery system based on transposon. Journal of Nanobiotechnology. 2021 Oct 2;19(1):303. 

7. Kaishun Hu#, Yu Li#, Wenjing Wu#, Limin Xie#, Haiyan Yan, Yuexin Cai, Dong Chen, Qiongchao Jiang, Lehang Lin, Zhen Chen, Jian-You Liao, Yin Zhang, H. Phillip Koeffler, Yin Dong* and Erwei Song*. ATM-dependent recruitment of BRD7 is required for transcriptional repression and DNA repair at DNA breaks flanking transcriptional active regions. Advanced Science. 2020.7,2000157.

8. Hu K#, Wu W#, Li Y#, Lin L, Chen D, Yan H, Xiao X, Chen H, Chen Z, Zhang Y, Xu S, Guo Y, Koeffler HP, Song E*, Yin Dong*. Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents. 2019 May;20(5). PubMed PMID: 30940648; EMBO Report.

9. Yin Zhang#, Yong-xin Huang#, Dan-lan Wang, Bing Yang, Hai-yan Yan, Le-hang Lin, Yun Li, Jie Chen, Li-min Xie, Yong-sheng Huang, Jian-you Liao, Kai-shun Hua, Jie-hua He, Phei Er Saw, Xiao-ding Xu, Dong Yin*. LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network. Theranostics. 2020; 10(23): 10823–10837.

10. Liao JY#*, Yang B#, Zhang YC, Wang XJ, Ye Y, Peng JW, Yang ZZ, He JH, Zhang Y, Hu K, Lin DC*, Yin Dong*. EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs). Nucleic Acids Research. 2020 Jan 8;48(D1):D307-D313.