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尹东
职称：研究员
科室：基础与转化医学研究中心
概述

招生专业：分子医学

职务：基础与转化医学研究中心 主任

联系方式：yind3@mail.sysu.edu.cn

 

粤港RNA医学联合实验室                  常务副主任

广东省恶性肿瘤表观遗传与基因调控重点实验室 常务副主任

 

学术兼职：

广东省医学会：   医学实验室建设与管理学分会     副主委

Springer Nature出版社杂志《 Cancer Gene Therapy 》 副主编              

 

一、简介：

尹东，研究员，博士生导师。中山大学孙逸仙纪念医院医学研究中心主任。从事肿瘤遗传与表观遗传研究20余载。

遗传物质变异的积累是肿瘤发生发展的重要原因。围绕肿瘤遗传和表观遗传学，聚焦肿瘤基因组。基因表达、核酸和组蛋白修饰、染色质重塑、DNA损伤修复等表观遗传改变，发现了多个促癌和抑癌基因，并阐明了其肿瘤发生发展，及耐药的关系。发表论文近百篇，总引用6900多次，H指数45（来自Google Scholar），其中以第一/通讯作者（含共同）在Nature、Advance Science、Cancer Research、Nucleic Acids Research、Clinical Cancer Research、Oncogene等杂志发表SCI研究论文60余篇。主持国自然8项（重点1项、面上7项），科技部重点研发子课题1项（组长），广东省广州市项目多项。授权专利8项。

我院医学研究中心已成为一个2万多平米的现代化实验室和高水平综合性医学科研基地，博士和硕士研究生导师30多名，先后获得了广州市重点实验室、广东省重点实验室（三次考核评估优秀）、广东省国际合作基地、科技部国际合作基地、科技部教育部引智基地、粤港联合实验室。为我院医教研人员、研究生及博士后等科研工作者提供先进的实验条件和技术体系。

 

二、主要研究方向

1. 肿瘤基因组学和肿瘤分子遗传学；

2. 肿瘤基因表观调控；

3. 肿瘤DNA损伤修复与耐药机制；

4. 肿瘤分子分型与分子诊断。

 

三、近期主持的课题（5项）

  1. 线粒体TCA循环异常活化促进POLQ蛋白琥珀酰化修饰和激活低保真性DNA损伤修复的机制及其与肿瘤耐药复发关系的研究
  2. 人工染色体复制、重组和遗传稳定的关键元件和分子机制研究， 
  3. TRIM28介导的RCC2蛋白SUMO化修饰调控细胞有丝分裂的机制和功能研究
  4. BRD7通过调控染色质重塑促进转录激活区域DNA双链断裂同源重组修复的分子机制及功能研究
  5. 福尔马林固定石蜡包埋（FFPE）标本表观基因组图谱重建技术研发与应用

 

四、代表论著 (#第一作者，*通讯作者)

  1. Chen H#, Li Y#, Li H#, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y*, Behrens A*, Yin Dong*, Zhang C*. NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. Nature. 2024 Jul 3. doi: 10.1038/s41586-024-07620-9
  2. Li W, Han Q, Zhu Y, Zhou Y, Zhang J, Wu W, Li Y, Liu L, Qiu Y, Hu K*, Yin Dong*. SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma. Oncogene. 2023 May;42(21):1728-1740
  3. Li Y, Chen H, Xie X, Yang B, Wang X, Zhang J, Qiao T, Guan J, Qiu Y, Huang YX, Tian D, Yao X, Lu D, Koeffler HP, Zhang Y*, Yin Dong*. PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells. Cancer Research. 2023 Feb 3;83(3):398-413
  4. Yongsheng Huang#, Qian Yang#, Yueyuan Zheng#, Lehang Lin#, Xin Xu, Xiu-E Xu, Tiago C Silva, Masaharu Hazawa, Li Peng, Haotian Cao, Yanbing Ding, Daning Lu, Benjamin P Berman, Li-Yan Xu*, En-Min Li*, Yin Dong*. Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma. Nucleic Acids Research. 2021 Aug 9;gkab679.
  5. Zhang Y, Huang YX, Jin X, Chen J, Peng L, Wang DL, Li Y, Yao XY, Liao JY, He JH, Hu K, Lu D, Guo Y*, Yin Dong*. Overexpression of lncRNAs with endogenous lengths and functions using a lncRNA delivery system based on transposon. J Nanobiotechnology. 2021 Oct 2;19(1):303.
  6. Kaishun Hu#, Yu Li#, Wenjing Wu#, Limin Xie#, Haiyan Yan, Yuexin Cai, Dong Chen, Qiongchao Jiang, Lehang Lin, Zhen Chen, Jian-You Liao, Yin Zhang, H. Phillip Koeffler, Yin Dong* and Erwei Song*. ATM-dependent recruitment of BRD7 is required for transcriptional repression and DNA repair at DNA breaks flanking transcriptional active regions. Advanced Science 2020.7,2000157
  7. Hengxing Chen#, Yun Li1#, Yu Li1, Zhen Chen, Limin Xie, Wenjia Li, Yuanxin Zhu, Hong Xue, H. Phillip Koeffler, Wenjing Wu，Kaishun Hu*, Yin Dong*. PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2. Theranostics. 2020; 10(22): 9984–10000
  8. Yin Zhang#, Yong-xin Huang#, Dan-lan Wang, Bing Yang, Hai-yan Yan, Le-hang Lin, Yun Li, Jie Chen, Li-min Xie, Yong-sheng Huang, Jian-you Liao, Kai-shun Hua, Jie-hua He, Phei Er Saw, Xiao-ding Xu, Yin Dong*. LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network. Theranostics. 2020; 10(23): 10823–10837
  9. He J#, Huang Z#, He M, Liao J, Zhang Q, Wang S, Xie L, Ouyang L, Koeffler HP, Yin Dong*, Liu A*. Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas. Mol Cancer. 2020;19(1):17
  10. Liao JY#*, Yang B#, Zhang YC, Wang XJ, Ye Y, Peng JW, Yang ZZ, He JH, Zhang Y, Hu K, Lin DC*, Yin Dong*. EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs). Nucleic Acids Res. 2020 Jan 8;48(D1):D307-D313..
  11. Hu K#, Wu W#, Li Y#, Lin L, Chen D, Yan H, Xiao X, Chen H, Chen Z, Zhang Y, Xu S, Guo Y, Koeffler HP, Song E*, Yin Dong*. Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.. 2019 May;20(5). PubMed PMID: 30940648; EMBO Report.
  12. Lehang Lin#, Moli Huang#, Xianping Shi#, Anand Mayakonda, Kaishun Hu, Yan-Yi Jiang, Xiao Guo, Li Chen, Brendan Pang, Ngan Doan, Jonathan W. Said, Jianjun Xie, Sigal Gery, Xu Cheng, Zhaoyu Lin, Jinsong Li, Benjamin P. Berman, Yin Dong*, De-Chen Lin*, H. Phillip Koeffler. Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. 2018. Nucleic Acids Research.
  13. De-Chen Lin#*, Anand Mayakonda, Huy Q Dinh, Pinbo Huang, Lehang Lin, Xiaoping Liu, Ling-Wen Ding, jie wang, Benjamin Berman, Erwei Song, Yin Dong* and H. Phillip Koeffler. Genomic and epigenomic heterogeneity of hepatocellular carcinoma. 2017. Cancer Research.
  14. De-Chen Lin#*, Liang Xu, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shizhu Yu, Michael Kahn, Yin Dong*, H. Phillip Koeffler. Genomic and functional analysis of the E3 ligase PARK2 in glioma. 2015, 75(9):1815-27. Cancer Research. 
  15. Yin Dong#*, Seishi Ogawa, Norihiko Kawamata, Amanda Leiter, Michelle Ham, Dong Li, Ngan B Doan, Jonathan W. Said, Keith L. Black, H. Phillip Koeffler (2013). miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme. 2013 Feb 28;32(9):1155-63. Oncogene.
  16. Yin Dong#*, Chen W, O'Kelly J, Lu D, Ham M, Doan NB, Xie D, Wang C, Vadgama J, Said，JW, Black KL, Koeffler HP. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. 2010. 127(10):2257-67. International Journal of Cancer
  17. Yin Dong#*, Naoki Wakimoto, Hongtao Xing, Daning Lu, Thien Huynh, Xiao Wang, Keith L. Black, H. Phillip Koeffler (2008). Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. 15;123(6):1364-75. International Journal of Cancer. 
  18. Yin Dong#*, John M. Ong, Jinwei Hu, Julian C. Desmond, Norihiko Kawamata, Bindu M Konda, Keith L. Black, H. Phillip Koeffler. （2007）SuberoylanilideHydroxamic Acid (SAHA), a Histone Deacetylase Inhibitor: Effects on Gene Expression and Growth of Glioma Cells in vitro and vivo. 13(3):1045-1052. Clinical Cancer Research.
  19. Yin Dong#*, Dong Xie, Sakura Sakajiri, Carl W. Miller, Hui Zhu, Miriam L. Popoviciu, Johathan W. Said, Keith L Black, and H. Phillip Koeffler. (2006) DLK1: Increased expression in gliomas and associated with oncogenic activities. 25:1852-1861. Oncogene
  20. Yin Dong#*, Hong Zhou, Kumagai Takashi, Gentao Liu, John M. Ong2 Keith L. Black, and H. Phillip Koeffler. (2005) Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastomamultiforme (GBM). 24: 344–354. Oncogene.
  21. Yin Dong#*, Dong Xie, Wolf-Karsten Hofmann, Carl W. Miller, Keith L Black, H. Phillip Koeffler. (2002) Methylation, Expression, and Mutation Analysis of the Cell Cycle Control Genes in Human Brain Tumors. 21:8372-8378. Oncogene.

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