职称：研究员

导师资格：博士生导师

招生专业：分子医学

联系方式：yind3@mail.sysu.edu.cn

一、简介：

遗传物质变异的积累是肿瘤发生发展的重要原因之一。多年来，围绕肿瘤的遗传和表观遗传学展开深入研究。包括肿瘤的基因突变和表达、核酸和组蛋白修饰、染色质重塑、DNA损伤修复等。发现多个肿瘤相关基因的遗传和表观遗传改变，揭示细胞周期调控异常与肿瘤发生发展，以及DNA损伤修复与肿瘤耐药的机制。发表论文近百篇，总引用6900多次，H指数45（来自Google Scholar），其中以第一/通讯作者（含共同）在Nature、Advance Science、Cancer Research、Nucleic Acids Research、Clinical Cancer Research、Oncogene等杂志发表SCI研究论文60余篇。

二、主要研究方向

1. 肿瘤基因组学和肿瘤分子遗传学；

2. 肿瘤基因表观调控；

3. 肿瘤DNA损伤修复与耐药机制；

4. 肿瘤分子分型与分子诊断。

三、代表论著 (#第一作者，*通讯作者)

1. Chen H#, Li Y#, Li H#, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y*, Behrens A*, Yin Dong*, Zhang C*. NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. Nature. 2024 Jul 3. doi: 10.1038/s41586-024-07620-9
2. Li W, Han Q, Zhu Y, Zhou Y, Zhang J, Wu W, Li Y, Liu L, Qiu Y, Hu K*, Yin Dong*. SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma. Oncogene. 2023 May;42(21):1728-1740
3. Li Y, Chen H, Xie X, Yang B, Wang X, Zhang J, Qiao T, Guan J, Qiu Y, Huang YX, Tian D, Yao X, Lu D, Koeffler HP, Zhang Y*, Yin Dong*. PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells. Cancer Research. 2023 Feb 3;83(3):398-413
4. Yongsheng Huang#, Qian Yang#, Yueyuan Zheng#, Lehang Lin#, Xin Xu, Xiu-E Xu, Tiago C Silva, Masaharu Hazawa, Li Peng, Haotian Cao, Yanbing Ding, Daning Lu, Benjamin P Berman, Li-Yan Xu*, En-Min Li*, Yin Dong*. Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma. Nucleic Acids Research. 2021 Aug 9;gkab679.
5. Kaishun Hu#, Yu Li#, Wenjing Wu#, Limin Xie#, Haiyan Yan, Yuexin Cai, Dong Chen, Qiongchao Jiang, Lehang Lin, Zhen Chen, Jian-You Liao, Yin Zhang, H. Phillip Koeffler, Yin Dong* and Erwei Song*. ATM-dependent recruitment of BRD7 is required for transcriptional repression and DNA repair at DNA breaks flanking transcriptional active regions. Advanced Science 2020.7,2000157
6. Hengxing Chen#, Yun Li1#, Yu Li1, Zhen Chen, Limin Xie, Wenjia Li, Yuanxin Zhu, Hong Xue, H. Phillip Koeffler, Wenjing Wu，Kaishun Hu*, Yin Dong*. PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2. Theranostics. 2020; 10(22): 9984–10000
7. He J#, Huang Z#, He M, Liao J, Zhang Q, Wang S, Xie L, Ouyang L, Koeffler HP, Yin Dong*, Liu A*. Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas. Mol Cancer. 2020;19(1):17
8. Hu K#, Wu W#, Li Y#, Lin L, Chen D, Yan H, Xiao X, Chen H, Chen Z, Zhang Y, Xu S, Guo Y, Koeffler HP, Song E*, Yin Dong*. Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.. 2019 May;20(5). PubMed PMID: 30940648; EMBO Report.
9. Lehang Lin#, Moli Huang#, Xianping Shi#, Anand Mayakonda, Kaishun Hu, Yan-Yi Jiang, Xiao Guo, Li Chen, Brendan Pang, Ngan Doan, Jonathan W. Said, Jianjun Xie, Sigal Gery, Xu Cheng, Zhaoyu Lin, Jinsong Li, Benjamin P. Berman, Yin Dong*, De-Chen Lin*, H. Phillip Koeffler. Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. 2018. Nucleic Acids Research.
10. De-Chen Lin#*, Anand Mayakonda, Huy Q Dinh, Pinbo Huang, Lehang Lin, Xiaoping Liu, Ling-Wen Ding, jie wang, Benjamin Berman, Erwei Song, Yin Dong* and H. Phillip Koeffler. Genomic and epigenomic heterogeneity of hepatocellular carcinoma. 2017. Cancer Research.
11. De-Chen Lin#*, Liang Xu, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shizhu Yu, Michael Kahn, Yin Dong*, H. Phillip Koeffler. Genomic and functional analysis of the E3 ligase PARK2 in glioma. 2015, 75(9):1815-27. Cancer Research. 
12. Yin Dong#*, Seishi Ogawa, Norihiko Kawamata, Amanda Leiter, Michelle Ham, Dong Li, Ngan B Doan, Jonathan W. Said, Keith L. Black, H. Phillip Koeffler (2013). miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme. 2013 Feb 28;32(9):1155-63. Oncogene.
13. Yin Dong#*, Chen W, O'Kelly J, Lu D, Ham M, Doan NB, Xie D, Wang C, Vadgama J, Said，JW, Black KL, Koeffler HP. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. 2010. 127(10):2257-67. International Journal of Cancer
14. Yin Dong#*, Naoki Wakimoto, Hongtao Xing, Daning Lu, Thien Huynh, Xiao Wang, Keith L. Black, H. Phillip Koeffler (2008). Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. 15;123(6):1364-75. International Journal of Cancer. 
15. Yin Dong#*, John M. Ong, Jinwei Hu, Julian C. Desmond, Norihiko Kawamata, Bindu M Konda, Keith L. Black, H. Phillip Koeffler. （2007）SuberoylanilideHydroxamic Acid (SAHA), a Histone Deacetylase Inhibitor: Effects on Gene Expression and Growth of Glioma Cells in vitro and vivo. 13(3):1045-1052. Clinical Cancer Research.
16. Yin Dong#*, Dong Xie, Sakura Sakajiri, Carl W. Miller, Hui Zhu, Miriam L. Popoviciu, Johathan W. Said, Keith L Black, and H. Phillip Koeffler. (2006) DLK1: Increased expression in gliomas and associated with oncogenic activities. 25:1852-1861. Oncogene
17. Yin Dong#*, Hong Zhou, Kumagai Takashi, Gentao Liu, John M. Ong2 Keith L. Black, and H. Phillip Koeffler. (2005) Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastomamultiforme (GBM). 24: 344–354. Oncogene.
18. Yin Dong#*, Dong Xie, Wolf-Karsten Hofmann, Carl W. Miller, Keith L Black, H. Phillip Koeffler. (2002) Methylation, Expression, and Mutation Analysis of the Cell Cycle Control Genes in Human Brain Tumors. 21:8372-8378. Oncogene.