2024年中山大学“百人计划”引进人才，副研究员，博士生导师。博士毕业于中山大学生命科学学院，导师屈良鹄教授，后在美国芝加哥大学何川院士和陈梦洁教授实验室接受博士后科研训练。多年来一直从事计算RNA组学和基因组学方面的研究，致力于开发新的计算分析方法解析新型RNA分子和修饰以及它们在转录及转录后水平的调控机制。截至目前，已在Nature Biotechnology（3篇）、Genome Biology、Molecular Cell和Nucleic Acid Research等国际著名期刊杂志发表论文二十余篇，部分研究论文被Nature Cell Biology、Trends in Genetics、Nature Genetics和Molecular Cell等杂志作为研究亮点进行评述。其中6篇研究论文入选ESI高被引论文，总引用次数超过6000次。以共同发明人授权/申请专利1项。

联系方式：liushun6@mail.sysu.edu.cn

课题组主要研究方向

（一）RNA修饰与肿瘤发生发展的分子机制

（二）RNA组学和基因组学计算分析工具和平台的开发

（二）RNA相关高通量测序数据的整合分析与挖掘，探索RNA如何参与遗传信息的表达调控及其功能验证

代表性研究论文（#第一作者，*通讯作者）

01. Shun Liu, Allen Zhu, Chuan He, Mengjie Chen*. REPIC: a database for exploring the N6-methyladenosine methylome. (2020). Genome Biology 21(1): 100.

02. Qiong Yu#, Shun Liu#, Lu Yu, Yu Xiao, Shasha Zhang, Xueping Wang, Yingying Xu, Hong Yu, Yulong Li, Junbo Yang, Jun Tang, Hong-Chao Duan, Lian-Huan Wei, Haiyan Zhang, Jiangbo Wei, Qian Tang, Chunling Wang, Wutong Zhang, Ye Wang, Peizhe Song, Qiang Lu, Wei Zhang, Shunqing Dong, Baoan Song*, Chuan He*, Guifang Jia*. RNA demethylation increases the yield and biomass of rice and potato plants in field trials. (2021). Nature Biotechnology 39(12): 1581-1588.

03. Lulu Hu#, Shun Liu#, Yong Peng#, Ruiqi Ge#, Rui Su#, Chamara Senevirathne, Bryan T. Harada, Qing Dai, Jiangbo Wei, Lisheng Zhang, Ziyang Hao, Liangzhi Luo, Huanyu Wang, Yuru Wang, Minkui Luo, Mengjie Chen*, Jianjun Chen*, Chuan He*. m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome. (2022). Nature Biotechnology 40(8): 1210-1219.

04. Yu-Lan Xiao#, Shun Liu#, Ruiqi Ge#, Yuan Wu, Chuan He*, Mengjie Chen*, Weixin Tang*. Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination. (2023). Nature Biotechnology 41(7):993-1003.

05. Fang Yu#, Allen C. Zhu#, Shun Liu#, Boyang Gao, Yuzhi Wang, Nelli Khudaverdyan, Chunjie Yu, Qiong Wu, Yunhan Jiang, Jikui Song, Lingtao Jin, Chuan He*, Zhijian Qian*. RBM33 is a unique m6A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity. (2023). Molecular Cell 83(12):2003-2019.e6.

06. Fang Yu#, Shun Liu#, Allen C. Zhu, Chuan He*, Zhijian Qian*. Protocol for detecting RBM33-binding sites in HEK293T cells using PAR-CLIP-seq. (2024). STAR Protocols 5(1):102855.

07. Yong Peng#, Hanzhe Meng#, Ruiqi Ge#, Shun Liu#, Mengjie Chen, Chuan He*, Lulu Hu*. Detection of m6A RNA modifications at single-nucleotide resolution using m6A-selective allyl chemical labeling and sequencing. (2022). STAR Protocols 3(4): 101677.

08. Shun Liu, Jun-Hao Li, Jie Wu, Ke-Ren Zhou, Hui Zhou, Jian-Hua Yang*, Liang-Hu Qu*. StarScan: a web server for scanning small RNA targets from degradome sequencing data. (2015). Nucleic Acids Res. 2015 Jul 1;43(W1):W480-6.

09. Jun-Hao Li#, Shun Liu#, Ling-Ling Zheng#, Jie Wu,Wen-Ju Sun, Ze-Lin Wang, Hui Zhou, Liang-Hu Qu* and Jian-HuaYang*. Discovery of protein–lncRNA interactions by integrating large-scale CLIP-Seq and RNA-Seq datasets. (2015). Frontiers in Bioengineering and Biotechnology 2:88.

参编专著

Zijie Zhang, Shun Liu, Chuan He, and Mengjie Chen. Recent Development of Computational Methods in the Field of Epitranscriptomics. Handbook of Statistical Bioinformatics. Springer, Berlin, Heidelberg. 2022 Dec;Second Edition:285-309.