副研究员，博士生导师，广东省“特支计划”科技创新青年拔尖人才。

研究领域：从2009年开始至今一直从事蛋白翻译后修饰与肿瘤基因组不稳定性、细胞周期调控紊乱及肿瘤放化疗、靶向治疗耐受等方面的分子机制研究，在肿瘤发生发展及耐药机制等方向取得一系列重要的原创性成果，共发表20多篇相关的第一或通讯(含共同)SCI学术论文，其中包括6篇影响因子>10，包括Journal of Clinical Investigation、Advanced Science、Molecular Psychiatry 、EMBO Report、Oncogene、Signal Transduction and Targeted Therapy等；作为项目负责人获得4项国家自然科学基金项目资助(青年基金1项，面上项目3项)，获批2项国家发明专利；Oncogene、Oncogenesis等期刊同行评议专家。

联系方式：huksh3@mail.sysu.edu.cn

主持的部分基金项目：

(1) 国家自然科学基金面上项目，82373150，2024/01-2027/12，48万元，在研，主持；

(2) 国家自然科学基金面上项目，82172636，2022/01-2025/12，55万元，在研，主持；

(3) 国家自然科学基金面上项目，81772821，2018/01-2021/12，52万元，已结题，主持；

(4) 国家自然科学基金青年项目，81301732，2014/01-2016/12，23万元，已结题，主持；

(5) 广东省特支计划“科技创新青年拔尖人才”项目，2021TQ06Y125，2022/11-2025/10，50万元，在研，主持；

近五年代表性论文(#第一作者，*通讯作者)：

1、Kaishun Hu^#(第一作者), Yu Li^#, Wenjing Wu^#, Limin Xie^#, Haiyan Yan, Yuexin Cai, Dong Chen, Qiongchao Jiang, Lehang Lin, Zhen Chen, Jian-You Liao, Yin Zhang, H Phillip Koeffler, Dong Yin*, Erwei Song*，ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions，Adv Sci (Weinh). 2020 Sep 3;7(20):2000157. (IF: 17.5). 

2、Kaishun Hu^#(第一作者), Wenjing Wu^#, Yu Li^#, Lehang Lin, Dong Chen, Haiyan Yan, Xing Xiao, Hengxing Chen, Zhen Chen, Yin Zhang, Shuangbing Xu, Yabin Guo, H Phillip Koeffler, Erwei Song*, Dong Yin*，Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents，EMBO Rep. 2019 May;20(5): e46166. (IF: 9.0). 

3、Wenjia Li^#, Qingfang Han^#, Yuanxin Zhu^#, Yingshi Zhou^#, Jingyuan Zhang, Weijun Wu, Yu Li, Long Liu, Yuntan Qiu, Kaishun Hu*(共同通讯作者), Dong Yin*，SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma. Oncogene. 2023 Apr 7. (IF: 8.7). 

4、Fangfang Qi^#, Zejie Zuo^#, Kaishun Hu^#(共同第一作者), Rui Wang, Tong Wu, Hao Liu, Jiaoling Tang, Qingbo Wang, Yufeng Xie, Liren Tan, Yunjie Yang, Xiaoran Zhang, Jiaying Zheng, Jie Xu, Zhibin Yao, Shengwen Wang*, Long-Jun Wu*, Kaihua Guo*，VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration. Mol Psychiatry. 2023 Jun 6. (IF: 13.4). 

5、Yang Yang^#, Yuedong Ma^#, Huabin Gao^#, Tingsheng Peng, Huijuan Shi Yunxiang Tang, Hui Li, Lin Chen, Kaishun Hu*(共同通讯作者), Anjia Han*，A novel HDGF-ALCAM axis promotes the metastasis of Ewing sarcoma via regulating the GTPases signaling pathway. Oncogene. 2021 Jan;40(4):731-745. (IF: 8.7). 

6、Liwen Zhou^#, Lisi Zheng^#, Kaishun Hu^#(共同第一作者), Xin Wang, Ruhua Zhang, Yezi Zou, Li Zhong, Shang Wang, Yuanzhong Wu*, Tiebang Kang*，SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites. Signal Transduct Target Ther. 2020 Jun 24;5(1):80. (IF: 38.4). 

7、Kaishun Hu^#(第一作者), Yu Li^#, Wenjing Wu^#, Hengxing Chen, Zhen Chen, Yin Zhang, Yabin Guo*, Dong Yin*. High-performance gene expression and knockout tools using sleeping beauty transposon system, Mob DNA. 2018 Nov 26; 9:33. (IF: 4.6)

8、Wenjing Wu^#, Jianli Zhao^#, Jianhong Xiao, Weijun Wu, Limin Xie, Xiaojuan Xie, Chaoye Yang, Dong Yin*, Kaishun Hu*(通讯作者). CHFR-mediated degradation of RNF126 confers sensitivity to PARP inhibitors in triple-negative breast cancer cells, Biochem Biophys Res Commun. 2021 Oct 8;573: 62-68. (IF：3.5)

9、Yu Li^#, Kaishun Hu^#(共同第一作者), Xing Xiao, Wenjing Wu, Haiyan Yan, Hengxing Chen, Zhen Chen, Dong Yin*. FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation, Biochem Biophys Res Commun. 2018 Mar 4;497(2):473-479. (IF：3.5)

10、Yu Li^#, Xing Xiao^#, Hengxing Chen, Zhen Chen, Kaishun Hu*(共同通讯作者), Dong Yin*. Transcription factor NFYA promotes G1/S cell cycle transition and cell proliferation by transactivating cyclin D1 and CDK4 in clear cell renal cell carcinoma, Am J Cancer Res. 2020 Aug 1;10(8):2446-2463. (IF：5.9)

11、Yumei Huang^#, Kaishun Hu^#(共同第一作者), Sheng Zhang^#, Xiaorong Dong, Zhongyuan Yin, Rui Meng, Yingchao Zhao, Xiaofang Dai, Tao Zhang, Kunyu Yang, Li Liu, Kai Huang, Shaojun Shi, Yu Zhang, Junjie Chen, Gang Wu*, Shuangbing Xu*. S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer, Theranostics. 2018 Feb 2;8(5):1286-1300. (IF：11.6)

12、Zhen Chen^#, Wenjing Wu^#, Yongsheng Huang, Limin Xie, Yu Li, Hengxing Chen, Wenjia Li, Dong Yin*, Kaishun Hu*(通讯作者). RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT. J Cancer. 2019 Nov 1;10(27):6837-6847. (IF：4.4)

13、Hengxing Chen^#, Yun Li^#, Yu Li, Zhen Chen, Limin Xie, Wenjia Li, Yuanxin Zhu, Hong Xue, H Phillip Koeffler, Wenjing Wu, Kaishun Hu*(共同通讯作者), Dong Yin*. PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2. Theranostics. 2020 Aug 8;10(22):9984-10000. (IF：11.6)