基础与转化医学研究中心
黄炳培
职称:研究员
科室:基础与转化医学研究中心
概述

黄炳培,研究员,于2009年获英国贝尔法斯特女王大学博士学位,回国后建立血管与肿瘤微环境实验室。现为中山大学孙逸仙纪念医院医学研究中心研究员、中山大学中山医学院生物化学与分子生物学教研室副主任、广东省杰出青年医学人才、博士生导师。多年来致力于将基础研究转化为临床应用,尤其对肿瘤微环境和癌症治疗开展系统性深入的研究,取得了丰硕的原创性学术成果: 1)发现了血管周细胞参与调控肿瘤微环境的新功能,为针对实体肿瘤的治疗提供了新策略;2)开创了靶向肿瘤耐药微环境治疗方法(VPT),为肺癌及胰腺癌治疗带来了新的曙光;3)揭示了肿瘤微环境调控肿瘤进展及耐药系列的新机制,发展了应用新的抑制剂替代或改善传统治疗的策略。研究成果发表在Cell、Nature、Cancer Cell等国际认可学术期刊上。2016年入选国家级海外青年人才引进项目,随后获得国家自然科学基金重点国际(地区)合作与交流项目、中山大学“百人计划”、中山大学孙逸仙纪念医院高层次人才特别支持计划“三个三”工程青年拔尖人才项目支持,主持国家自然科学基金面上、重点国际(地区)合作与交流项目、广州市科技重大专项等项目,共获得科研资助达1000余万人民币。

 

联系方式:huangbp3@mail.sysu.edu.cn

 

代表性论文著作成果:

 

1.    Cancer burden is controlled by mural cell-b3-integrin regulated crosstalk with tumor cells.Wong PP#,*, Muñoz-Félix JM#,*, Hijazi M, Kim H, Robinson S, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O, Meng YM, Meng Q, Bodrug N, Dukinfield MS, Reynolds LE, Elia G, Clear A, Harwood C, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Matchett KP, Henderson NC, Szlosarek PW, Dreger SA, Smith S, Jones JL, Gribben JG, Cutillas PR, Meier P, Sanz-Moreno V and Hodivala-Dilke KM* Cell 2020, 181, 1-18<<IF:38.637>>

2.    Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductaladeno-carcinomas by upregulating N-linked glycosylation of CDK11p110. Chen Y#, Su L#, Huang C, Wu S, Qiu X, Zaho X, Meng Q, Meng YM, Kong X, Wang M*, Liu C*, Wong PP*.Cancer Letters 2021, 500, 228-243. <<IF:7.36>>

3.   A circular network of coregulated sphingolipids dictates lung cancer growth and progression. Meng Q#, Hu X#, Zhao X#, Kong X#, Meng YM, Chen Y, Su L, Jiang X, Qiu X, Huang C, Liu C*, Wang M*, Wong PP*. EBiomedicine 2021 In Press <<IF:5.76>>.

4.    Pericyte FAK negatively regulates Gas6/Axl signaling to suppress tumor angiogenesis and tumor growth. Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Escudero J, Munoz-Felix J, Batista S, Dukinfield M, Demircioglu F, Wong PP, Matchett KP, Henderson NC, D’Amico G, Parsons M, Harwood C, Meier P, Hodivala-Dilke KM. Nature Communications 2020, 11, 2810 <<IF:11.878>>

5.    Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Chen F, Chen J, Yang L, Liu J, Zhang X, Zhang Y, Tu Q, Yin D, Lin D, Wong PP, Huang D, Xing Y, Zhao J, Li M, Liu Q, Su F, Su S*, Song E*. Nature Cell Biology 2019 Apr;21(4):498-510 <<IF:20.042>>

6.    Exploring novel methods for modulating tumor blood vessels in cancer treatment.

Wong PP, Bodrug N, Hodivala-Dilke KM*. Current Biology 2016 Nov 7:26(21):R1161-R1166 <<IF:9.601>>

7.   Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread. Wong PP, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford M, Scudamore C, Cereser B, Crnogorac-Jurcevic T, McDonald S,Elia G, Hagemann T, Kocher HM, and Hodivala-Dilke KM*. Cancer Cell 2015 Jan 12;27(1):123-137 <<IF:26.602>>

8.    Endothelial-cell FAK targeting sensitizes tumors to DNA-damaging therapy. Tavora B, Reynolds LE, Batista S, Demircioglu F, Fernandez I, Lechertier T, Lees DM, Wong PP, Alexopoulou A, Elia G, Clear A, Ledoux A, Hunter J, Perkins N, Gribben JG, Hodivala-Dilke KM*. Nature 2014 Oct 2;514(7520):112-6 <<IF:43.07>>

9.    Identification of MAGEA antigens as causal players in the development of tamoxifen resistant breast cancer. Wong PP#,*, Yeoh CC#, Ahmad AS, Chelala C, Gillett C, Speirs V, Jones JL, Hurst HC*. Oncogene2014 Sep 11;33(37):4579-88 <<IF:7.971>>

 

 

中国专利:

黄炳培,等。一种肿瘤组织中周细胞的分离和仿生培养方法。国家知识产权局,专利授权号:201810550545.8