中山大学孙逸仙纪念医院副研究员，硕士生导师，基础与转化医学研究中心课题组负责人（PI），入选“逸仙优秀青年医学人才”项目。研究方向：肿瘤靶向治疗研究。相关研究成果发表在Nano Letters, Advanced Science, Journal of Controlled Release, Theranostics, Small Methods等学术期刊，发表论文30余篇。主持包括国家自然科学基金青年项目、广东省自然科学基金青年项目和中国博士后科学基金面上项目等。

联系方式：xulei56@mail.sysu.edu.cn

代表性工作：

1. Rui Xu, Phei Er Saw, Lei Xu*, Long-circulating theranostic 2D metal-organic frameworks with concurrent O₂ self-supplying and GSH depletion characteristic for enhanced cancer chemodynamic therapy. Small Methods, 2022, 6, 2200178.     
2. Yuan Cao^#, Zixuan Zhao^#, Junyue Fang^#, Yanan Lu, Zhuoshan Huang, Guo Wu, Qiyuan Gao, Rong Li, Lei Xu*, and Xiaoding Xu*, Dual-responsive immunomodulatory RNAi nanoplatform for effective immune checkpoint blockade and enhanced cancer immunotherapy. Advanced Healthcare Materials, 2025, 2500646. 
3. Zhen Zhang^#, Liang Huang^#, Gaocheng Gai, Bingbing Xie, Yijing Zhao, Lei Xu*, Qiuling Xiang*. Dual ROS modulation by MnO₂-integrated collagen hydrogel enhances hiPSC-derived endothelial progenitor cell therapy for critical limb ischemia. Theranostics, 2026, 16 (11), 6164-6183.
4. Wenhao Li^#, Jiaman Qu^#, Weifan Li^#, Yuan Cao, Rui Xu* and Lei Xu*. Targeting obesity and adipokine signaling in breast cancer microenvironment for enhanced tumor therapy. Nanoscale, 2026, DOI: 10.1039/D5NR05009J.
5. Yixia Liang^#, Shuwen Cao^#, Xuanping Deng^#, Jiabao Tan, Guo Wu, Shiyu Tan, Xiaoding Xu, Jiyi Yao, Lei Xu*, Phei Er Saw*, Nanoparticles-mediated SLAMF7 overexpression regulates TME for enhanced immunotherapy of solid tumors. Materials & Design, 2026, 263, 115564. 
6. Yuan Cao^#, Rui Xu^#, Yixia Liang, Jiabao Tan, Xiaotang Guo, Junyue Fang, Shibo Wang*, Lei Xu*, Nature-inspired protein mineralization strategies for nanoparticle construction: advancing effective cancer therapy. Nanoscale, 2024, 16, 13718-13754.
7. Lei Xu^#, Zhuoshan Huang^#, Wenyue Zhang, Yuan Cao, Xiaotang Guo, Bo Hu, Rong Li, Qiusheng Lan*, Xiaoding Xu*, A robust RNAi nanoplatform for precise activation of cGAS-STING pathway and effective immune checkpoint blockade to potentiate cancer immunotherapy. Journal of Controlled Release, 2026, 392, 114690. 
8. Lei Xu^#, Rui Xu^#, Phei Er Saw, Jun Wu, Sixue Cheng, and Xiaoding Xu*, Nanoparticle-mediated inhibition of mitochondrial glutaminolysis to amplify oxidative stress for combination cancer therapy. Nano Letters, 2021, 21, 7569-7578. 
9. Lei Xu, Shibo Wang, Chang Xu, Di Han, Xiaohe Ren, Xianzheng Zhang, Sixue Cheng*, Multifunctional albumin-based delivery system generated by programmed assembly for tumor-targeted multimodal therapy and imaging. ACS Applied Materials & Interfaces, 2019, 11, 38385-38394.
10. Lei Xu^#, Yuan Cao^#, Ya Xu, Rong Li, and Xiaoding Xu*, Redox-Responsive Polymeric Nanoparticle for Nucleic Acid Delivery and Cancer Therapy: Progress, Opportunities, and Challenges. Macromolecular Bioscience 2023, 2300238.
11. Lei Xu, Xiaoyan He, Boya Liu, Chang Xu, Shulun Ai, Renxi Zhuo, Sixue Cheng*, Aptamer-functionalized albumin-based nanoparticles for targeted drug delivery. Colloids and Surfaces B: Biointerfaces 2018, 171, 24-30.
12. Senlin Li^#, Lei Xu^#, Guo Wu, Ziqi Huang, Linzhuo Huang, Fengqian Zhang, Chunfang Wei, Qian Shen, Rong Li, Lei Zhang*, and Xiaoding Xu*, Remodeling serine synthesis and metabolism via nanoparticles (NPs)-mediated CFL1 silencing to enhance the sensitivity of hepatocellular carcinoma to sorafenib. Advanced Science, 2023, 2207118.
13. Ke Yang^#, Lei Xu^#, Ying Xu^#, Senlin Li, Qingjian Li, Tao Qin, Yunfang Yu, Hai Hu, Herui Yao*, and Xiaoding Xu*, Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis. Acta Pharmaceutica Sinica B, 2023, 13(8), 3489e3502.
14. Xiaoqiong Huang^#, Lei Xu^#, Xiaoran Yu^#, Yiming Li, Ziqing Huang, Ruogu Xu, Wenyi Zeng, Zhengchuan Zhang, Weichang Li, Feilong Deng*, Near-infrared light-responsive multifunctional hydrogel releasing peptide-functionalized gold nanorods sequentially for diabetic wound healing. Journal of Colloid and Interface Science, 2023, 639, 369-384.