尹东，研究员，博士生导师。中山大学孙逸仙纪念医院医学研究中心主任；广东省恶性肿瘤表观遗传与基因调控重点实验室常务副主任；粤港RNA医学联合实验室常务副主任。

从事肿瘤基因调控和表观遗传学研究20多年，先后以第一/通讯作者在Advance Science、Hepatology、Nucleic Acids Research、Cancer Research、Clinical Cancer Research、Molecular Cancer、Leukemia 、Oncogene、Molecular Cancer Research、International Journal of Cancer等国际知名的肿瘤学学术期刊上发表SCI研究论文40余篇。主持国家自然科学基金国际合作重点和面上项目7项、广东省协同创新与平台建设国际合作领域和创新团队项目4项、广州市健康医疗协同创新重大专项等多项。2000-2012曾作为博士后、助教授和副教授在美国加州大学洛杉矶分校医学院（UCLA）Cedars-Sinai医学中心学习和工作12年。2011年底回国，任中山大学孙逸仙纪念医院医研中心主任，完善了医研中心建设，使之成为一个高水平综合性的医学科研平台，为研究生及科研人员提供良好的实验场地和技术支持。协助医院获批了广东省恶性肿瘤表观遗传与基因调控重点实验室（2013，2016和2019年2次考核评估中获得优秀），科技部国际合作基地（2016）、科技部教育部111引智基地（2019）、粤港RNA医学联合实验室（2020）。

联系方式：yind3@mail.sysu.edu.cn

发表论著 (#第一作者，*通讯作者)

1. Liao, J.Y#*., Yang, B., Zhang, Y.C., Wang, X.J., Ye, Y., Peng, J.W., Yang, Z.Z., He, J.H., Zhang, Y., Hu, K. Lin, D.C.* and Yin Dong*. (2019) EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs). Nucleic acids research. 
2. YT Li, Nan Zhou, Wei-xi Deng, Xue-zhen Zeng, Jian-you Liao*, Dong Yin*. CIRDES: an efficient genome-wide method for in vivo RNA-RNA interactome analysis[J]. Analyst, 2019.8 (https:// doi.org/10.1039/ C9AN01054H), Cover article.

3. Hu K#, Wu W#, Li Y#, Lin L, Chen D, Yan H, Xiao X, Chen H, Chen Z, Zhang Y, Xu S, Guo Y, Koeffler HP, Song E*, Yin Dong*. Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.. 2019 May;20(5). PubMed PMID: 30940648; EMBO Report.

4. Lehang Lin#, Moli Huang#, Xianping Shi#, Anand Mayakonda, Kaishun Hu, Yan-Yi Jiang, Xiao Guo, Li Chen, Brendan Pang, Ngan Doan, Jonathan W. Said, Jianjun Xie, Sigal Gery, Xu Cheng, Zhaoyu Lin, Jinsong Li, Benjamin P. Berman, Dong Yin*, De-Chen Lin*, H. Phillip Koeffler. Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. 2018. Nucleic Acids Research.

5. De-Chen Lin#*, Anand Mayakonda, Huy Q Dinh, Pinbo Huang, Lehang Lin, Xiaoping Liu, Ling-Wen Ding, jie wang, Benjamin Berman, Erwei Song, Dong Yin* and H. Phillip Koeffler. Genomic and epigenomic heterogeneity of hepatocellular carcinoma. 2017. Cancer Research. 

6. Huang P#, Zhuang B#, Zhang H#, Yan H, Xiao Z, Li W, Zhang J, Tang Q, Hu K, Koeffler HP, Wang J*, Dong Yin*. Hepatitis B virus X protein (HBx) is responsible for resistance to targeted therapies in hepatocellular carcinoma: ex vivo culture evidence. 2015 Oct 1;21(19):4420-30. Clin Cancer Research.

7. De-Chen Lin#*, Liang Xu, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shizhu Yu, Michael Kahn, Dong Yin*, H. Phillip Koeffler. Genomic and functional analysis of the E3 ligase PARK2 in glioma. 2015, 75(9):1815-27. Cancer Research. 

8. Dong Yin#*, Seishi Ogawa, Norihiko Kawamata, Amanda Leiter, Michelle Ham, Dong Li, Ngan B Doan, Jonathan W. Said, Keith L. Black, H. Phillip Koeffler (2013). miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme. 2013 Feb 28;32(9):1155-63. Oncogene.

9. Yin Z#, Liu C, Chen Y, Bai Y, Shang C, Yin R, Dong Yin*, Wang J*. Timing of hepatectomy in resectable synchronous colorectal liver metastases (SCRLM): Simultaneous or Delayed? 2013 Jun;57(6):2346-57. Hepatology. 

10. Dong Yin#*, Chen W, O'Kelly J, Lu D, Ham M, Doan NB, Xie D, Wang C, Vadgama J, Said，JW, Black KL, Koeffler HP. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. 2010. 127(10):2257-67. International Journal of Cancer.